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Frontline Plus for Extra Large Dogs over 89 lbs (Red)

Rated 4.6/5 (514 Reviews)

Price $42.89

Deal Price $27.88

Pack

3 Doses 6 Doses

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Shop Other Pack Sizes

Frontline Plus for Small Dogs up to 22lbs (Orange)

$31.89

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Frontline Plus for Medium Dogs 23-44 lbs (Blue)

$36.89

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Frontline Plus for Large Dogs 45-88 lbs (Purple)

$39.89

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Combo Offers

Frontline Plus & Heartgard Plus Combo

$47.33

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Combo Offers

Frontline Plus & Nuheart Combo

$36.91

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Frontline Plus for Small Dogs up to 22lbs (Orange)

$31.89

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Frontline Plus for Medium Dogs 23-44 lbs (Blue)

$36.89

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Frontline Plus for Large Dogs 45-88 lbs (Purple)

$39.89

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Frontline Plus & Heartgard Plus Combo

$47.33

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Frontline Plus & Nuheart Combo

$36.91

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Description

Frontline Plus Red for Extra Large Dogs (89 - 132lbs)

Frontline Plus Red for Extra Large Dogs is a fast-acting and waterproof topical treatment for fleas and ticks on dogs weighing between 89 lbs and 132 lbs. This effective spot-on formulation kills adult fleas, flea eggs, and flea larvae and prevents all flea life stages from developing. It breaks the flea cycle to prevent re-infestations and flea allergy dermatitis. Furthermore, it helps eliminate chewing lice infestations and aids in the control of sarcoptic mange infestations.

Frontline Plus Spot-on for Dogskills all life stages of ticks (larva, nymph, and adult), including brown dog ticks (Rhipicephalus sanguineus), American dog ticks (Dermacentor variabilis), lone star ticks (Amblyomma americanum), and deer ticks (Ixodes scapularis). It may also help prevent tick-borne diseases like Lyme disease, Rocky Mountain spotted fever, haemobartonellosis, ehrlichiosis, babesiosis, anaplasmosis, etc., as a result of its quick action against fleas.

Frontline Plus flea and tick treatment is formulated with the active ingredients fipronil and (S)-methoprene. When you apply this treatment on your dog's skin, these ingredients spread from the single point of application, rapidly covering the entire dog and localizing in the hair, on the surface of the skin, and in the sebaceous glands. These glands act as a reservoir, continuously replenishing the solution onto the skin and hair coat, so it keeps working even if the dog gets wet.

Fleas, ticks, and chewing lice do not need to bite your dog in order to die, as this treatment kills them on contact. When the parasites come in contact with a treated dog, they get killed by the action of active ingredients. This unique formulation is starts killing adult fleas, ticks, and chewing lice within a few hours of application.

One long-lasting dose of this treatment ensures full protection for up to 30 days, and year-round monthly treatment is recommended for continuous protection. Frontline Plus for Extra Large Dogs is safe to use on extra-large-sized dogs of all ages from 8 weeks, weighing between 89lbs and 132 lbs, as well as breeding, pregnant, and lactating dogs.

Key Benefits

Kills adult fleas and ticks on your dog
Fast-acting and long-lasting treatment
Convenient monthly spot-on
Effective against adult fleas, flea eggs, and flea larvae
Also works against chewing lice and sarcoptes mites
Works to kill various types of ticks on dogs
Helps prevent tick-borne diseases in dogs, including Lyme disease
Breaks the flea cycle and prevents new infestations
Waterproof when the dog is allowed to remain dry for 24 hours after application

How To Use

Read the product label and instructions carefully before use.
Do not use more than one application per dog per month.
Ensure that the dog remains dry for 24 hours after application.
Do not apply to dogs weighing less than 5 lbs. for small dogs, 23 lbs. for medium dogs, 45 lbs. for large dogs, and 89 lbs. for extra-large dogs or younger than 8 weeks of age. Do not use two applicators for dogs weighing more than 132 lbs. Do not use more than one application per dog per month.

STEP ONE

1. Let the puppy or dog stand in a comfortable position. Part the fur between the shoulder blades to make the skin visible.

STEP TWO

2. Peel the foil to remove the pipette. Hold upright with the foil side toward you and snap the applicator tip. Next, place the tip directly onto the visible skin.

STEP THREE

3. Squeeze out the solution in one spot until the pipette is empty. Allow the area to be completely dry.

Follow Frontline Plus dosage chart for dog given below for appropriate pack size:

Pack Color	Dog Weight	Dog Size	Dose Content	Strength
Orange	Up to 22 lbs	Small Dogs	0.67 ml	9.8% of Fipronil and 8.8% of S-methoprene
Blue	23-44 lbs	Medium Dogs	1.34 ml	9.8% Fipronil and 8.8% of S-methoprene
Purple	45-88 lbs	Large Dogs	2.68 ml	9.8% of Fipronil and 8.8% of S-methoprene
Red	89-132 lbs	Extra Large Dogs	4.02 ml	9.8% of Fipronil and 8.8% S-methoprene

Safety

Formulated for dogs only. Do not use it on rabbits or other animals.
Until the application site is dry, keep children and other pets away from grooming or playing with the treated pet.
Avoid contact with the treated area until dry.
Keep away from children. If swallowed, then immediately contact a poison control center.
In case the product enters a pet's eyes, flush with lots of water and contact a veterinarian.
Sterilize hands after treating the pet.
Do not drink, eat, or smoke while applying the treatment.
Consult a veterinarian before treating aged, convalescing, and debilitated pets.

More Information

Frequently Asked Questions (FAQs) Frontline Plus for Dogs

Q. What is Frontline Plus for Dogs?

Frontline Plus is a trusted flea and tick protection treatment for dogs. The easy-to-use spot-on treatment also works against chewing lice and sarcoptic mites on dogs.

Q. How does Frontline Plus for Dogs work?

Frontline Plus for Dogs spreads from the single point of application, rapidly covering the entire dog and localizing in the hair, on the surface of the skin, and in the sebaceous glands. These glands act as a reservoir, continuously replenishing the active ingredients, fipronil and (s)-methoprene, onto the skin and hair coat, so it keeps working even if the dog gets wet.

Q. How often do I need to use Frontline Plus for Dogs?

Frontline Plus needs to be administered every month, preferably on the same date, for continuous protection against fleas and ticks.

Q. Do I need to use other flea & tick treatments while using Frontline Plus for Dogs?

No, you should not use other flea and tick treatments while using Frontline Plus for Dogs, as it is designed to be used as a standalone monthly treatment.

Q. How long does it take for Frontline Plus for Dogs to start working?

Frontline Plus starts working quickly within a few hours of application.

Q. Is it safe to use Frontline Plus on dogs?

Frontline Plus for Dogs is specifically formulated and approved for use on dogs from 8 weeks of age, weighing at least 5 lbs. It is also approved for use on pregnant, lactating, and breeding dogs.

Q. Does Frontline Plus kill ear mites?

No, Frontline Plus is not intended to kill ear mites.

Ingredients

Fipronil
(S)-methoprene

Customer Reviews (514)

Average Rating

4.6

Julia

Frontline Plus Oct 19, 2025

This has always worked for us. We live on the edge of woods & need protection for our animals.

7 of 14 found this review helpful.

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Henry

Effective Oct 11, 2025

Used it for years and it never disappoints, my dog stays flea-free all season.

11 of 18 found this review helpful.

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Janet

Frontline plus Oct 07, 2025

I have been using this product for several years now and to date I have no issues or problems with ticks or associated ailments from ticks. My dog is pleased.!

7 of 14 found this review helpful.

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Jacklyn

Frontline Plus For Dogs Oct 05, 2025

I’ve been using this product on my dogs for years and it always combats any flea and tick problems that they might have. Budget Pet Care is a great source for buying this and other pet products that they offer! I rate this company and products a 20 out of 10!

20 of 28 found this review helpful.

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Kate

Very effective Oct 03, 2025

We went camping and came back with zero ticks thanks to this.

9 of 17 found this review helpful.

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Related to this item

Frontline Plus for Extra Large Dogs over 89 lbs (Red)

Frontline Plus Red for Extra Large Dogs (89 - 132lbs)

Frequently Asked Questions (FAQs) Frontline Plus for Dogs

Q. What is Frontline Plus for Dogs?

Q. How does Frontline Plus for Dogs work?

Q. How often do I need to use Frontline Plus for Dogs?

Q. Do I need to use other flea & tick treatments while using Frontline Plus for Dogs?

Q. How long does it take for Frontline Plus for Dogs to start working?

Q. Is it safe to use Frontline Plus on dogs?

Q. Does Frontline Plus kill ear mites?

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