Extra 60% off
I really appreciate the buysafe guarantee - I feel much safer and confident in your company by having this added safety measure. I will surely use your company in the future!
R Khan
It is nice to have peace of mind when ordering from an unfamiliar site. It was nice to see you had "buySAFE". Thank you
T Smith
Secure Payment Processing
PCI DSS Complaint, Allied Wallet, Paypal
256 bit SSL Encryption
Question from Coleen Love


American Short Hair, age 2-1/2 years

Jasper gets bumps on his neck when fleas are bothering him. A friend even noticed that he seemed to drink water funny - sips then raises his head. He was given Comfortis two days ago and we bombed the house with Hot Shot canisters 5 days ago... yet tonight I saw a flea jumping off him and his neck has not cleared up, but rather gotten worse. I am ready to start using liquid Program on our four animals. Do I need to worry about drug interactions since he has just had Comfortis a few days ago?
Our Vet Says:

There is no record of any adverse reaction between Program Plus and Comfortis, but every dog is different. My advice is not to give another medicine with Comfortis. Don’t give any medication for 2 weeks. Spinosad (the active ingredient for Comfortis) has been shown to be a substrate for P-glycoprotein (PgP). Spinosad could therefore interact with other PgP-substrates (for example, digoxin and doxorubicin) and possibly enhance adverse reactions from such molecules or compromise efficacy interaction.

My advice is to treat your pet and your house and yard at the same time. Repeat the treatment of your house after 2 weeks.


The answers or information contained on this site are for informational purposes only. The materials in this web site are in no way intended to replace the professional care, advice, diagnosis or treatment of a veterinary surgeon. The web site does not have answers to all problems. Answers to specific problems may not apply to everyone. Consult your veterinarian for any problem your pet has. Under no circumstances shall BudgetPetCare or any of its associates be liable for any damages resulting from the use of the service or the information contained therein. Please refer to our terms and conditions.

Customer Login

$100 Winner

Question of the Month

Congratulations to the winner of this month's Question of the Month, billy g. who wins $100 for the following question:

Ask a Vet winner

My dog has an itching problem. I use medicated shampoo with no results. I think she has dry skin and no lesions. I can use 1% hydrocortisone spray for temporary relief. I give her fish oil caps occasionally. Any suggestions?...??

Callout Winner Ask a Vet
> View our vet's reply