Further information for Advantage
A clear yellow to slightly brownish free-flowing non-aqueous solution containing 10 % w/v imidacloprid. The product is presented in a single use plastic pipette for cutaneous (spot-on) treatment in dogs, cats and pet rabbits.
Imidacloprid has a high affinity for the nicotinergic acetylcholine receptors in the post-synaptic region of the central nervous system (CNS). The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptor sites and the postulated poor penetration through the blood/brain barrier in mammals, it has virtually no effect on the mammalian CNS. The minimal pharmacological activity in mammals is supported by safety studies involving systemic administration of sub-lethal doses to rabbits, mice and rats.
Oral studies in the rat show imidacloprid to be absorbed rapidly from the gastro-intestinal tract. Almost complete absorption (95%) occurs within 48 hours. Peak plasma concentrations are observed within 2.5 hours following administration. Tissue distribution is also rapid with the lowest levels recorded in the brain. The active ingredient undergoes extensive metabolism with only 10-16% remaining as parent compound. Almost complete (96%) elimination occurs within 48 hours.
For the prevention and treatment of flea infestations on cats and dogs, and for the treatment of biting lice (Trichodectes canis) on dogs.
For the treatment of flea infestations on pet rabbits.
Fleas are killed within one day following treatment. One treatment prevents further flea infestation on dogs for up to four weeks, three to four weeks on cats and up to one week on pet rabbits. The product can be used as part of a treatment strategy for flea allergy dermatitis in the cat and the dog. The treatment should be repeated after 4 weeks.
Advantage ll contains imidacloprid and insect growth regulator (IGR) pyriproxyfen. Insect growth regulator (IGR) pyriproxyfen inhibits development of flea eggs and larvae to break the flea life cycle, so fleas are not able to reproduce. The treatment should be repeated after 4 weeks
Both product are manufactured by Bayer