Nexgard Plus Vs. Simparica Trio – Comparing Two Broad-Spectrum Dog Treatments

Vet-recommended Nexgard Plus vs simparica trio are broad spectrum treatments.

Not one dog parent in the world would want to see their furry friends suffering from parasites, never. Parasites like fleas, ticks, and worms not only make the lives of our canine friends miserable but also leave a lasting effect on both animals and their human caretakers. Therefore, we must do everything in our power to keep them protected from these blood-suckers. And the best way to do this is by providing them with effectual treatment. But when there is an ocean of treatment options available, it is hard to choose one that works best for your pupper.

Nexgard Plus and Simparica Trio are a couple of popular antiparasitics for dogs. This blog compares these two well-liked brands and helps you pick one for your friend.

Nexgard Plus & Simparica Trio – Comprehensive Comparison

About The Brands

Recommended for 8 weeks and older puppies and dogs that weigh at least 4 lbs, Nexgard Plus is a palatable beef-flavored broad-spectrum treatment. One Nexgard Plus dose every month protects dogs from fleas, ticks, heartworm disease, and intestinal worms.

Simparica Trio is an all-in-one monthly treatment that protects dogs against both external and internal parasites including fleas, ticks, heartworm disease, and intestinal worms. Puppies and dogs that weigh 2.8 lbs or more and are 8 weeks or older can use this formula.

Common Attributes

Nexgard Plus and Simparica Trio share a few characteristics. Take a look at what they have in common.

Dog Age:

Recommending both for use in puppies and dogs from 8 weeks of age.

Monthly Oral Chew:

Both are formulated in a tasty chew form that should be administered orally. Each of these treatments protects dogs for one month.

Similar Parasitic Coverage:

Both prevent heartworm disease, kill adult fleas, and treat and prevent flea infestations.

Either of these treatments is effective against American dog ticks, black-legged ticks, brown dog ticks, and lone star ticks.

Both Nexgard Plus and Simparica Trio are useful in the treatment and control of two roundworm species (Toxocara canis and Toxascaris leonina).

Uncommon Characteristics

Now, have a glance at the atypical attributes of Nexgard Plus and Simparica Trio.


Nexgard Plus is made of afoxolaner, moxidectin, and pyrantel. Simparica Trio contains sarolaner, moxidectin, and pyrantel.

Minimum Dog Weight:

Nexgard Plus should be used in 4 lbs or greater puppies and dogs. Simparica Trio on the other hand should be administered to puppies and dogs with at least 2.8 lbs weight.

Chew Flavor:

Nexgard Plus offers a delicious beef flavor and Simparica comes with a palatable liver flavor.

Difference in Parasitic Coverage:

Nexgard Plus protects against Black-legged ticks, American dog ticks, brown dogs, and Lone Star ticks. In addition to Black-legged tick, American dog tick, brown dog, and Lone star tick, Simparica Trio protects against Gulf Coast Tick infestations.

Simparica Trio effectively kills black-legged ticks. To prevent Lyme disease in dogs, use this product. Nexgard Plus does not protect dogs from Lyme disease.

Nexgard Plus treats and controls infections of three hookworm species (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala). Simparica Trio is useful in the treatment and control of two hookworm species (Ancylostoma caninum and Uncinaria stenocephala).

Comparison of Features

Now, take a look at the table below that showcases a comparison of Nexgard Plus and Simparica Trio product characteristics:

Key comparison Table for Nexgard plus vs simparica trio

Nexgard Plus vs Simparica Trio: The Summary

Vet-recommending Nexgard Plus and Simparica Trio are broad-spectrum treatments that guard dogs against internal and external parasites for a month.

Both Nexgard Plus and Simparica Trio are equally effective in protecting your canines against various parasites. Not only do they prevent fleas and different types of ticks, but they also guard against heartworm disease. Moreover, they protect against a couple of hookworm and roundworm species.

Talking about distinctive attributes, Nexgard Plus is effective against three hookworm species and the uncommon one is Ancylostoma braziliense. Simparica Trio treats and controls Gulf Coast tick infestation. Ultimately, we recommend you consider all the aspects and select the treatment that best suits your and your pet’s requirements. Do not skip consulting a veterinarian beforehand.

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