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Product Information

Frontline Plus is called Frontline Combo in the U.K. but contain the same active ingredients.

Box Color
Green
Frontline® Plus for cats Frontline® Combo for cats
Version USA Version UK Version
Reg. No. EPA Reg. No. 65331-4 VMD MA Vm 08327/4210
Dosage 0.017 fl oz (0.5 ml) 0.5 mL
Ingredients 9.8% Fipronil & 11.8% (S)-Methoprene (by weight) 100 g/L Fipronil & 120 g/L (S)-Methoprene
For Cats 8 weeks or older 8 weeks or older
Box Color
Orange
Frontline® Plus for dogs Frontline® Combo for dogs
Version USA Version UK Version
Reg. No. EPA Reg. No. 65331-5 VMD MA Vm 08327/4211
Dosage 0.023 fl oz (0.67 mL) 0.67 ml
Ingredients 9.8% Fipronil & 8.8%
(S)-Methoprene (by weight)
100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs Up to 22 lbs Up to 10kg
Box Color
Blue
Frontline® Plus for dogs Frontline® Combo for dogs
Version USA Version UK Version
Reg. No. EPA Reg. No. 65331-5 VMD MA Vm 08327/4212
Dosage 0.045 fl oz (1.34 mL) 1.34 mL
Ingredients 9.8% Fipronil & 8.8%
(S)-Methoprene (by weight)
100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs 23-44 lbs 10kg -20kg
Box Color
Purple
Frontline® Plus for dogs Frontline® Combo for dogs
Version USA Version UK Version
Reg. No. EPA Reg. No. 65331-5 VMD MA Vm 08327/4213
Dosage 0.091 fl oz (2.68 mL) 2.68 mL
Ingredients 9.8% Fipronil & 8.8%
(S)-Methoprene (by weight)
100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs 45-88 lbs 20kg -40kg
Box Color
Red
Frontline® Plus for dogs Frontline® Combo for dogs
Version USA Version UK Version
Reg. No. EPA Reg. No. 65331-5 VMD MA Vm 08327/4214
Dosage 0.136 fl oz (4.02 mL) 4.02 mL
Ingredients 9.8% Fipronil & 8.8%
(S)-Methoprene (by weight)
100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs 89-132 lbs 40kg -60kg
Product Disclaimer:

Frontline Combo has been approved for sale in the UK by the Veterinary Medicines Directorate.

The US equivalent of this product has been approved for sale by the EPA.

Both the UK and US products contain the same active ingredients, Fipronil & (S)-Methoprene.

The UK packaging does not have EPA approval.

If swallowed call a poison control center or doctor immediately for treatment advice. For hazards to domestic animals the 24 hour assistance line within the U.S.A. is 1-800-660-1842.

The Product Information Schedule above indicates some of the material differences between the UK and U.S.A. versions.




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My Maddy is 6 years old and a HUGE girl -170 lbs. and the sweetest girl in my world! Trouble is... She is miserable with the itching. I been to the vet and tried changing her food to no beef, chicken, or pork. I also had her on allergy pills that cost $140 a month. I simply can’t afford that plus the expensive dog food, plus continuous yard treatments, etc. can you recommend a flea pill that is affordable? She is also on prion for incontinence. Will it affect that medication too? Thank ...?

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