Frontline Plus & Frontline Combo

Product Information

Frontline Plus is called Frontline Combo in the U.K. but contain the same active ingredients.

Box Color Green	Frontline® Plus for cats	Frontline® Combo for cats

Version	USA Version	UK Version
Reg. No.	EPA Reg. No. 65331-4	VMD MA Vm 08327/4210
Dosage	0.017 fl oz (0.5 ml)	0.5 mL
Ingredients	9.8% Fipronil & 11.8% (S)-Methoprene (by weight)	100 g/L Fipronil & 120 g/L (S)-Methoprene
For Cats	8 weeks or older	8 weeks or older

Box Color Orange	Frontline® Plus for dogs	Frontline® Combo for dogs

Version	USA Version	UK Version
Reg. No.	EPA Reg. No. 65331-5	VMD MA Vm 08327/4211
Dosage	0.023 fl oz (0.67 mL)	0.67 ml
Ingredients	9.8% Fipronil & 8.8% (S)-Methoprene (by weight)	100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs	Up to 22 lbs	Up to 10kg

Box Color Blue	Frontline® Plus for dogs	Frontline® Combo for dogs

Version	USA Version	UK Version
Reg. No.	EPA Reg. No. 65331-5	VMD MA Vm 08327/4212
Dosage	0.045 fl oz (1.34 mL)	1.34 mL
Ingredients	9.8% Fipronil & 8.8% (S)-Methoprene (by weight)	100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs	23-44 lbs	10kg -20kg

Box Color Purple	Frontline® Plus for dogs	Frontline® Combo for dogs

Version	USA Version	UK Version
Reg. No.	EPA Reg. No. 65331-5	VMD MA Vm 08327/4213
Dosage	0.091 fl oz (2.68 mL)	2.68 mL
Ingredients	9.8% Fipronil & 8.8% (S)-Methoprene (by weight)	100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs	45-88 lbs	20kg -40kg

Box Color Red	Frontline® Plus for dogs	Frontline® Combo for dogs

Version	USA Version	UK Version
Reg. No.	EPA Reg. No. 65331-5	VMD MA Vm 08327/4214
Dosage	0.136 fl oz (4.02 mL)	4.02 mL
Ingredients	9.8% Fipronil & 8.8% (S)-Methoprene (by weight)	100 g/L Fipronil & 90 g/L (S)-Methoprene
For Dogs	89-132 lbs	40kg -60kg

Product Disclaimer:

Frontline Combo has been approved for sale in the UK by the Veterinary Medicines Directorate.

The US equivalent of this product has been approved for sale by the EPA.

Both the UK and US products contain the same active ingredients, Fipronil & (S)-Methoprene.

The UK packaging does not have EPA approval.

If swallowed call a poison control center or doctor immediately for treatment advice. For hazards to domestic animals the 24 hour assistance line within the U.S.A. is 1-800-660-1842.

The Product Information Schedule above indicates some of the material differences between the UK and U.S.A. versions.

Product Information

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